A business model for incompetent “IT” products

This paper proposes a business model – one that affects vendors of IT products that have officially been determined to be commercially unviable in the marketplace and are set to be permanently decommissioned. The paper proposes to channel the usage of these products for use by non-profit enterprises. The vendors of incompetent IT products, implying the products have been rendered commercially unviable, make exit decisions on these products thereby killing an otherwise usable product and making it extinct, instead of considering the use of the product by non-profit organizations. As a result, commercially unsustainable products cease to exist altogether instead of getting recycled for reuse by non-profit organizations

The Inter-Organizationa; System (IOS) Artifact: an Interpretaticce Discourse

A need for theory-based research covering IOS artifact has been cited by IS academics and researchers, wherein the subject of the research is the IOS itself, as opposed to the contexts within which the IOS gets acceptance. This paper attempts to define a simple proposition pertinent to the IOS artifact and in doing so identifies areas of research interest, which if pursued could potentially lead to theories for IOS that are explanatory, instructive and stand the test of IOS evolution

Redox and substitution reactions of <i>trans</i>-(diaqua)(N, N'-ethylenebis(salicylideneaminato)cobalt(lll) with hexacyanoferrate(ll, lll): A proton coupled electron transfer reaction

1062-1067The electron transfer between trans-[Co(Salen)(OH2)2]+ (Salen N, N'-ethylenebis(salicylideneaminato) and (Fe(CN)6]4- involved a binuclear species, [(OH2)Colll(Salen)- (NCFeIlCN5)]3-, as an intermediate. The kinetics of the formation of this binuclear species and the one formed by the reaction of the title complex with [FeCN6]3- have been studied at 20-35°C (I = 0.5 mol dm- 3); the data are consistent with the Id mechanism. Both spontaneous and H + coupled paths are identified for the electron transfer within the binuclear species of hexacyanoferrate(II) which further undergoes electron transfer with [FeCN6]4- via a second order path

Cystic metastasis versus brain abscess: Role of MR imaging in accurate diagnosis and implications on treatment

Intracranial cystic metastases are difficult to differentiate from non neoplastic lesions like a cystic abscess on routine magnetic resonance imaging (MRI) sequences in patients with a known primary cancer. Diffusion weighted MRI sequences can help in differentiating between the two. This carries significant implications on the intent and nature of treatment. We present a case of a forty five-year- old patient of squamous cell carcinoma of larynx who developed an intracranial cystic ring enhancing lesion following chemotherapy. Though routine MRI was equivocal, MR diffusion was highly suggestive of an abscess and this led to surgical excision which confirmed the diagnosis. We discuss this case and review the literature regarding the role of newer MRI sequences and the ramifications on patient treatment

Kinetics and mechanism of the reaction of <em>trans-(diaqua)(N,N' - </em>ethylene bis-(salicylidineiminato)cobalt(III) with ascorbic acid

947-960The kinetics of the reactions of trans-[Co(Salen)(OH2)2]+ (Salen = N.N¢-ethylene bis (salicylidineiminate) ·jth ascorbic acid (H2Asc) have been studied under varying conditions of pH, [ascorbic acid]T, and temperature at .5 mol dm-3 ionic strength. The initial fast reactions observed in the stopped flow time scale are due to the complex formation between the reactants. This occurs in two phases i.e., the formation of the trans- [(2 ua)(ascorbato)CoIII(Salen)] and its transformation to the corresponding ascorbate chelate. The rate constants are the activation parameters for the formation of the monobonded and chelate ascorbate complexes are reported. T low values of ΔH+ and negative values of ΔS+ for the complexation reaction favour associative interchange mechanism(la). The hydroxide in trans-[Co(Salen)(OH)(OH2)] marginally accelerates substitution of the aqua and by HAsc- and the trans-[Co(Salen)(OH)(AscH)]- is considered to undergo fast internal proton transfer to .nerate trans-[Co(Salen)(OH2)(Asc)]- which undergoes chelation of the Colll centre by the bound ascorbate noiety; the latter reaction is, however, 15 times slower than the corresponding reaction of trans- [Co(Salen)(OH2)(AscH)]. The faster complexation reactions are followed by the slow redox reactions. The rate constant for the internal reduction of Colll by the coordinated ascorbate in the chelate [Co(Salen)(AscH)] is 5 - 10 times (25°C – 45°C) faster than the same for [Co(Salen)(Asc)]-. This trend in reactivity is due to the low value of ΔH for the former although the high negative value of ΔS compensates at least partly the overriding effect of the activation enthalpy. The internal redox occurs via innersphere mechanism. We also have observed a redox path involving trans-[Co(Salen)(OH2)(AscH2)]+ and H2Asc for which electron transfer most likely involves outersphere mechanism

Clinical studies with Cannabis in India – A need for guidelines for the investigators and ethics committees

Cannabis is one of the world's oldest cultivated plants and the most commonly used recreational drug worldwide. The plant relevant for medicinal use is Cannabis sativa that has two pharmacologically active ingredients – delta-9-tetrahydrocannabinol that is psychoactive and cannabidiol that does not have psychotropic activity. The policy tapestry of Cannabis has undergone a significant change in the past few decades worldwide. Different countries have diverse policies, ranging from classifying use of Cannabis as illicit, to legalization of its use, both for medicinal and recreational purposes. Cannabis products are approved for use, for instance, in multiple sclerosis and Dravet syndrome (US Food Drug and Administration). Against this backdrop, we find that the knowledge foundations for use of Cannabis in clinical trials in India are still evolving. Conducting ethical research within a clinical trials framework is essential to understand dosing, formulation, shelf life, drug–drug interaction, tolerability, and safety before establishing its utility for various indications. In the absence of guidelines or a regulatory framework for conduct of these studies, the various Institutional Ethics Committees (IECs), which are responsible for reviewing projects related to Cannabis, face unique challenges with respect to the basic requirements. The principal investigators (PIs) are equally strained to find local guidance, recommendations, and literature in support of their application to the respective IEC, thus leading to an impasse and delay in initiating the proposed clinical studies with Cannabis. The present article addresses considerations, questions, and issues that affect the conduct of these clinical studies and recommends mandatory documents and some suggested guidelines for use by both PIs and IECs to take studies with Cannabis forward until such time that an interdisciplinary regulatory framework is firmed up by regulatory authority

Cystic metastasis versus brain abscess: Role of MR imaging in accurate diagnosis and implications on treatment

Intracranial cystic metastases are difficult to differentiate from non neoplastic lesions like a cystic abscess on routine magnetic resonance imaging (MRI) sequences in patients with a known primary cancer. Diffusion weighted MRI sequences can help in differentiating between the two. This carries significant implications on the intent and nature of treatment. We present a case of a forty five-year- old patient of squamous cell carcinoma of larynx who developed an intracranial cystic ring enhancing lesion following chemotherapy. Though routine MRI was equivocal, MR diffusion was highly suggestive of an abscess and this led to surgical excision which confirmed the diagnosis. We discuss this case and review the literature regarding the role of newer MRI sequences and the ramifications on patient treatment